We use non-thermal plasma to make nitric oxide from air and develop it for wound care, as a treatment gas or held in a liquid. We are looking for research and development partners.
One plasma source, three ways to use the nitric oxide it makes. Each is at a different stage.
Treatment gas from our non-thermal gliding arc, rich in nitric oxide and other reactive nitrogen species. Only the gas touches the wound, not the plasma.
A working system that produces the treatment gas is built and running. Its nitric oxide output is shown in the results below.
Next step. Wound-care testing of the gas is planned. Our current focus is storing NO in liquid compounds.
Nitric oxide made from air and electricity. A gas vortex stretches the arc along the full length of the electrode, and gas flow and power set the output.
85 ppm NO in the outlet gas at an air flow of 30 L/min and about 0.9 kW, from a single reading. The slowed-down video shows the vortex driving the arc channel around the reactor wall.
A plasma-treated N-acetylcysteine (NAC) solution that holds nitric oxide and releases it on demand. Available to research partners as a research-use reagent.
During treatment the solution turns from colourless to bright pink within about 10 minutes, and its sulfur odour disappears. The colour stays until NO starts to be released, then fades. A pink colour that fades as NO leaves is typical of S-nitrosothiols. We are now confirming this with UV-Vis scans of fresh samples taken during treatment.
NO release is measured in the headspace with a calibrated electrochemical detector. Chemical identity: UV-Vis and nitrite/nitrate tests, published in Plasma Medicine.
Next step. Measure the S-nitrosothiol (RSNO) content directly with the Saville assay, then in vitro work on release kinetics and antimicrobial and antibiofilm activity against P. aeruginosa and S. aureus.
3 min of treatment: still clear
10 min: bright pink
After NO release: colour goneEach result is tied to a specific system and test. All of our work is at the research stage.
85 ppm NO
Made from ambient air at 30 L/min and about 0.9 kW. Single reading; repeat runs are next.
The results below are for the liquid platform: N-acetylcysteine (NAC) solution treated with gliding arc plasma. RSNO is the form we are working to confirm; a direct RSNO assay is next.
NO is held in the liquid and released on agitation: about 1 ppm at rest, more with longer shaking.
Mean ± SD over repeated agitation cycles of the same 40 mL aliquot: 13 cycles at 5 s, 3 at 1 min, 8 at 2 min. One batch. On an orbital shaker (150 RPM, 2 h) the signal levelled at 29 to 31 ppm, with a peak of 44 ppm.
40 mL of solution in a sealed 50 mL bottle (10 mL headspace), 21.5 °C, day 22 after production. Calibrated FD-90A electrochemical NO detector, 0 to 250 ppm range.
A separate measurement of the same batch on day 21 showed the same pattern: about 2 ppm at 5 s, 7 ppm at 25 s, 10 ppm at 1 min and 12 to 20 ppm at 2 min (9 cycles, mean 16 ppm). The signal did not fall to zero after 24 agitation cycles. The day 22 values are higher because that run used a fresh aliquot that had not been agitated before.
Published in Plasma Medicine, 2026, in the context of preservation. Laboratory and storage results, not tests on living tissue.
Quartz UV-Vis, 280 to 700 nm. A small rise in visible absorbance versus untreated NAC, but no distinct S–NO band near 340 nm, so UV-Vis alone does not confirm RSNO.
May 2026, quartz cuvettes, 1:10 dilution. About 3× at 545 nm (0.0058 vs 0.0019 absorbance).
The signal dropped between day 22 and day 27, and the batch was still releasing NO after about two months.
Made in April 2026 at 40 L/min and about 1 kW, stored sealed at room temperature. Day 22: 8 agitation cycles. Day 27: 5 cycles. About two months: one reading; the exact day was not recorded, so the point is placed at day 60 within a shaded range.
The two-month point used a shorter agitation (20 s instead of 2 min), so it is not directly comparable with the first two points.
15 ppm NO
3.8 L treated in one 10-minute run. Twenty days later it still released NO on shaking, with nitrite at 0 on a test strip.
Single reading. The headspace is about ten times larger than in the 50 mL bottle above, which dilutes the NO, so the ppm values are not directly comparable.
The people behind Plasma NO Medical Group.
Leads the company and its partnerships.
Podiatrist who advises on wound-relevant study design and the clinical direction of our work.
We work with clinics, universities, research labs and medical device companies.
Run studies with us, or test our systems and reagents in your own lab and publish what you find.
We adapt plasma and NO technology to a specific medical use and define the prototype your study needs.
Talk to us about licensing the technology for your medical application and bringing a product to market together.
Every project starts with a short call to agree on the question you want answered. After that we take one of two paths:
Our technologies are for research use. They are not approved or cleared by the FDA and are not available for clinical use.
Tell us what you are working on and which technology interests you. We will reply within a few working days.
Or write to us at info@plasmanomed.com